Molecule

Pharmacist

6.0/10
Molecule
Not specified
Office / on-site
mid
about 4 hours ago
AI SummaryVerified by Aipplify AI

The vacancy is well-defined but lacks compensation details, affecting overall quality.

AI quality score6.5 / 10

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Overview

Molecule is seeking a Pharmacist to build the formulation function from scratch, focusing on cognitive and performance compounds. Join a team at the intersection of biotech, blockchain, and AI. Molecule and BIO.xyz are building the foundation of Decentralized Science (DeSci) โ€” where biotech meets web3 to make scientific research community-owned, transparent, and faster to market. Molecule provides the infrastructure to turn intellectual property (IP) into programmable, on-chain assets through our IP-NFT framework and evolving protocol stack. This enables researchers, patients, and communities to fund and govern biotech projects in new, open ways. BIO.xyz is the coordination and economic layer of DeSci, powering BioDAOs through funding, governance, and ecosystem alignment. Together, we are creating a new model for scientific discovery โ€” one where breakthroughs are owned and advanced by the communities that believe in them.

What You'll Do

  • โ€ขDesign oral solid-dose formulations (capsules and tablets) from active properties up - excipient selection, diluents, binders, disintegrants, flow agents, and lubricants matched to each compound's solubility, stability, and dosing profile
  • โ€ขDesign sterile injectable formulations for our peptide pipeline - lyophile design, bulking agents, cryoprotectants, vial fill/finish at small scale, reconstitution protocols, and container-closure compatibility. Hands-on with EU GMP Annex 1 (sterile manufacturing) and applicable AMG/AMWHV requirements
  • โ€ขOwn encapsulation, blending, and aseptic processing end to end: powder characterization, blend uniformity, content uniformity, capsule fill weight control, scale-up from bench to production batches, and sterility assurance for the injectable side
  • โ€ขSolve hard actives. Bromantane and modafinil bring oral-side challenges - low aqueous solubility, poor flow, dose accuracy at small fill weights. Peptides like BPC-157, GLP-1 analogs, and GHK-Cu bring injectable-side challenges - stability across the lyophile/reconstitution cycle, copper-complex integrity, peptide aggregation. You develop the techniques that make all of them reproducible
  • โ€ขBuild and run the analytical backbone: dissolution testing, assay/potency, content and weight uniformity, sterility (Ph. Eur. 2.6.1), endotoxin (Ph. Eur. 2.6.14), and stability programs (ICH Q1A - accelerated and long-term) to establish shelf life
  • โ€ขWrite documentation that holds up: master formulation records, batch records, specifications, and SOPs. Define what "in spec" means and enforce it. Clean data trails or it didn't happen
  • โ€ขPartner with sourcing and QC on raw-material specs, incoming API characterization (identity, purity by HPLC, particle size), and supplier qualification. Build a qualified supplier network. Continuously improve - reduce variability, improve stability, lower cost-per-dose without compromising quality

What We Offer

  • โ€ขA senior IC seat building the formulation function from scratch at a company at the intersection of biotech, blockchain, and AI
  • โ€ขPre-approved capex - you spec the equipment: lyophilizer, capsule filler, balance suite, HPLC, dissolution apparatus, Class II BSC
  • โ€ขThe team you need, once you've proven the foundation

Who You Are

  • โ€ขDefends decisions with data. You'd rather run the test than guess. When asked why you chose X over Y, you have a data-grounded answer
  • โ€ขHigh bar on accuracy and sterility. It's people's health. Dose accuracy, reproducibility, and sterility are non-negotiable - especially on injectables
  • โ€ขExpert in the room alone. You work well as the sole expert on day one. No team around you for the first year, and that doesn't slow you down
  • โ€ขEngineers around complexity. You see the regulatory complexity of the compound classes we work with clearly, and you engineer around it rather than pretending it isn't there

Required

  • โ€ขApprobation als Apotheker/in (German pharmacist license), or an EU-recognized pharmacy qualification with a clear path to German licensure. Alternatively: a degree in pharmaceutics, pharmaceutical sciences, or industrial pharmacy (MSc/PhD) with equivalent hands-on formulation depth
  • โ€ข5+ years of hands-on formulation experience in pharma, nutraceutical, compounding, or contract manufacturing - covering oral solid dose and at least one of: sterile injectables, topicals
  • โ€ขDeep working knowledge of excipient functionality and compatibility, and of encapsulation/tableting unit operations
  • โ€ขPractical command of dissolution, content uniformity, and stability study design and interpretation
  • โ€ขExperience formulating poorly-soluble or low-dose actives
  • โ€ขWorking command of EU GMP (EudraLex Vol. 4), Annex 1 (sterile manufacturing), and the Apothekenbetriebsordnung (ApBetrO) or equivalent manufacturing-pharmacy framework
  • โ€ขRigor with documentation: batch records, specs, SOPs, and a clean data trail

Strongly Preferred

  • โ€ขSterile injectable / lyophilization experience - peptide formulations specifically
  • โ€ขBackground in a German Herstellungsapotheke, hospital pharmacy compounding unit, or EU-licensed contract manufacturer
  • โ€ขExperience formulating GLP-1 analogs (semaglutide, tirzepatide) or other peptide manufacturing under a quality-grade framework
  • โ€ขFamiliarity with cognitive/performance compounds, or with the broader peptide / longevity therapeutic landscape
  • โ€ขHands-on with HPLC, dissolution apparatus, particle sizing, Karl Fischer titration
  • โ€ขComfort owning scale-up from R&D batches to production
  • โ€ขWorking proficiency in German (regulatory and documentation context) and English (team working language)
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